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Actos should probably be the first-line choice, over Avandia, he said. Clifford Rosen, of the Maine Center for Osteoporosis, who headed the recent FDA advisory committee panel that recommended Avandia stay on the market, albeit with stronger warnings. Steven Nissen, chairman of the Department of Cardiovascular Medicine at the Cleveland Clinic, published a study that found Avandia showed a 43 percent greater risk of heart attack among diabetes patients, and he remains convinced that the drug should not be used. Initiation of Avandia in patients with established NYHA Class III or IV heart failure is contraindicated. Haffner of the University of Texas Health Science Center faxed the article to the maker of Avandia, GlaxoSmithKline, after Haffner agreed to read the unpublished work as part of the journal's peer-review process, The New York Times reported.
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